RFantibody
Baker Lab / IPD (University of Washington)
RFdiffusion fine-tuned for de novo antibody design. Generates VHHs, scFvs, and full antibodies targeting user-specified epitopes. Experimentally validated with cryo-EM.
Best For
De novo antibody/nanobody generation against defined epitopes
License
Open Source (check repo)
Strengths
- +Atomic accuracy confirmed by cryo-EM
- +VHH + scFv + full IgG
- +Published in Nature 2025
Limitations
- −Requires screening 100s-1000s of designs
- −Computationally intensive
R&D Pipeline Coverage
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