DiffAb
Luo et al. (NeurIPS 2022)
Diffusion-based generative model that jointly designs antibody CDR sequences and 3D structures conditioned on antigen structure.
Best For
De novo CDR generation for known antigen targets
License
Open Source (check repo)
Strengths
- +Joint sequence + structure design
- +Antigen-conditioned generation
Limitations
- −Requires antigen 3D structure
- −CDR-H3 recovery lags newer methods
R&D Pipeline Coverage
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More in Antibody Design
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