ESM3

Inverse folding model: generates amino acid sequences predicted to fold into a target 3D backbone structure. Standard component of all modern protein design pipelines.

Programmable generative model for protein and protein complex design using diffusion with conditioning on geometry, symmetry, and functional annotations.

Diffusion-based generative model for de novo protein backbone design. Generates novel protein structures conditioned on binding targets, symmetry, or functional sites.

Successor to RFdiffusion using flow matching. Designs enzymes directly from active site geometry (theozyme) specifications.

Inverse folding model: generates amino acid sequences predicted to fold into a target 3D backbone structure. Standard component of all modern protein design pipelines.