Boltz-2
MIT + Recursion Pharmaceuticals
Extends Boltz-1 to jointly predict 3D complex structure AND protein-ligand binding affinity. Approaches FEP accuracy at 1,000x lower compute cost.
Best For
Structure + affinity prediction in one model; fast alternative to FEP calculations
License
Open Source (MIT)
Strengths
- +Structure + affinity in single model
- +1000x faster than FEP
- +MIT license
- +18 seconds per prediction
Limitations
- −Very new (June 2025)
- −Affinity predictions not fully validated across diverse scaffolds
- −Not a replacement for late-stage FEP
R&D Pipeline Coverage
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